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. 2019 Mar 15;11(3):1498–1509.

Figure 5.

Figure 5

LXR is a downstream target of AMPK. To confirm that LXR is a downstream target of AMPK, pretreatment with LXR agonist (GW3965, 5 μM) was applied to HepG2 cells exposed to FFA + Fetuin B siRNA. A: Intercellular TG content: FFA + Rec FetB vs. FFA + siFetB + GW3965 (P = 0.005); B: The expression of key proteins in the AMPK and LXR pathways; C: The mRNA levels of lipid metabolic enzymes; siFetB, siRNA fetuin B. Results are the mean ± SD of three independent experiments, each repeated in triplicate.