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. 2019 Mar 15;11(3):1498–1509.

Figure 6.

Figure 6

Fetuin B knockdown attenuated hepatic lipogenesis in mice fed a HFD. Hepatic lipid accumulation and the AMPK-/LXR-pathways were evaluated after fetuin B knockdown in mice exposed to a HFD. A: H&E staining and Oil Red O staining: HFD vs. HFD + shRNA (400 ×); B: Intrahepatic TG content (P < 0.001); C: Serum TG (P = 0.003); D: Liver enzymes; E: Key protein expression of the AMPK and LXR pathways in mouse liver; F: The mRNA levels of lipid metabolic enzymes; ALT, alanine transaminase; AST, aspartate transaminase. Results are the mean ± SD of three independent experiments (n = 6, each group).