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. 2019 Mar 15;11(3):1835–1842.

Figure 2.

Figure 2

miR-214 targets the 3’-UTR of lncRNA LINC00341 in the VSMCs. A. Subcellular fractionation analysis revealed the location of LINC00341 in the cytoplasm and nucleus. B. Online bioinformatics tools (StarBase v2.0, RegRNA2) suggested the complementary pairing within LINC00341 and miR-214. C. Luciferase gene reporter analysis showed the luciferase activity within the LINC00341 (wild type or mutant) and miR-214 or control. D. RNA immunoprecipitation (RIP) assay revealed the efficient molecular binding within LINC00341 and miR-214. E. RT-PCR revealed the LINC00341 and miR-214 in the VSMCs administrated with increasing concentration of ox-LDL (0-150 mg/l). F. miR-214 expression in the VSMCs transfected with the si-LINC00341. **P < 0.01 vs. si-NC control. *P < 0.05 vs. si-NC control.