Table 4.
SLE susceptibility genes
| SLE susceptibility genes | Induction factors | Symptoms |
|---|---|---|
| p53 codon 72 (rs1042522) | Minimum winter, temperature, latitude, summer downward solar radiation. | Rheumatoidarthritis, SLE. |
| MDM2 SNP 309 (rs2279744) | Minimum winter, temperature, latitude, summer downward solar radiation. | Aggravating the development of SLE and lupus nephritis in a mouse model of lupus. |
| PCDH18 (SNP rs2313132) | Summer UVR. | SLE genetic susceptibility. |
| HLA-DQA1 SNP rs2187668 | Humidity. | SLE genetic susceptibility. |
| TP53 (rs1042522) | Latitude, minimum winter temperature, summer shortwave radiation. | Discoid erythema. |
| HLA-C (rs10484554) | Summer precipitation rate. | Leucopenia, alopecia, fever. |
| TLR6 (rs5743810) | Winter UVR. | Pericarditis, oralulcers photosensitivity. |
| RPTOR (SNP rs11868112) | Latitude, winter Temperature. | Susceptibility to Autoimmune diseases. |