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. 2019 Apr 9;9:133. doi: 10.1038/s41398-019-0466-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Table of module-trait relationship reports Kendall’s correlation coefficients, and its corresponding p values, between the eigengene value of each module and the particular treatments. Modules related to R. flavefaciens treatment, and were not correlated with the same directionality with duloxetine treatment, are emphasized by dashed lines. b–g Gene ontology (GO) and protein-protein interaction (PPI) network analysis of WGCNA modules significantly related to R. flavefaciens treatment. GO enrichment analyses (b) and PPI network analysis (c, d) of genes in blue module with module membership (MM) > 0.7. GO enrichment analyses (e) and PPI network analysis (f) of genes in turquoise module with MM > 0.7. GO enrichment analyses of genes in skyblue module, with MM > 0.7 (g) Bars representing GO terms show Benjamini and Hochberg FDR adjusted p values. Node size in PPI networks indicates number of interactions with other nodes in the network (i.e., degree centrality), while the node color reflects number of shortest paths that rely on that given node within the network (i.e., betweenness centrality). dul duloxetine, Rum R. flavefaciens