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. 2019 Apr 9;9:5800. doi: 10.1038/s41598-019-41701-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The representative photomicrographs show immunostaining of MEDAG, PPARG and ORO staining of normal thyroid and thyroid carcinomas. In normal thyroid samples, MEDAG staining was negative (A), and in some cases, PPARG immunostaining was negative (B), but ORO staining was positive (C). Lipid droplets were rarely found in PTMC (F), even though MEDAG and PPARG were highly expressed (D,E). There was a statistically significant association between the MEDAG over expression and PPARG expression (G). The ORO staining scores were different between paracancer and PTMC samples (P = 0.00009) (H). The potential for metabolic reprogramming was observed in PTMC (I). Yellow triangles show the lipid droplets in the cytoplasm. *Fisher’s Exact Test, **Wilcoxon test. Original magnifications: B × 100; A,C–F × 400.