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. 2019 Apr 9;9:5839. doi: 10.1038/s41598-019-42303-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Reduced DUSP10 expression decreases chemosensitivity in shB7-H3 cells. (A) Left panel; Immunoblot analysis of phospho-p38 (p-p38), p38, and GAPDH expression upon DTIC treatment and right panel; average of three independent immunoblot values of p-p38 levels divided by p38 levels ± SEM in FEMX-I shSCR and shB7-H3 cells upon DUSP10 knockdown by siRNA. (B) Average proliferation of three independent experiments ± SEM of FEMX-I shSCR and shB7-H3 cells with DUSP10 knockdown and DTIC treatment as measured by the Incucyte FLR imaging system 72 h after treatment.