Table 3.

Associations of systemic factors with size of flow voids (dependent variable) in hypertensive participants (n = 164 eyes).

	Univariate			Multivariate-adjusted
	β	95% CI	P value	β	95% CI	P value
Age, per 10 years	0.27	0.11 to 0.43	0.001	0.21	0.06 to 0.36	0.006
Gender	−0.02	−0.33 to 0.29	0.894	0.07	−0.22 to 0.36	0.638
Diabetes	0.52	0.03 to 1.01	0.039	0.27	−0.17 to 0.72	0.226
Type of antihypertensive medications
Beta blockers	−0.09	−0.41 to 0.24	0.593	—	—	—
Calcium channel blockers	0.29	−0.01 to 0.59	0.062	0.31	0.04 to 0.57	0.024
Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers	−0.02	−0.32 to 0.29	0.921	—	—	—
Others (diuretics, alpha 2 adrenergic agonist)	−0.05	−0.42 to 0.33	0.805	—	—	—
Numbers of antihypertensive medications
One	Reference			Reference
Two	0.07	−0.28 to 0.41	0.696	—	—	—
Three or more	0.11	−0.37 to 0.60	0.653	—	—	—
BP control status
Intensive BP control	Reference			Reference
Standard BP control	−0.15	−0.53 to 0.23	0.433	—	—	—
Poor BP control	0.11	−0.38 to 0.60	0.666	—	—	—
Systolic BP
Systolic BP, overall, per 10 mmHg	−0.03	−0.15 to 0.09	0.634	—	—	—
Systolic BP, day, per 10 mmHg	−0.04	−0.15 to 0.08	0.534	—	—	—
Systolic BP, night, per 10 mmHg	0.00	−0.12 to 0.11	0.952	—	—	—
Diastolic BP
Diastolic BP, overall, per 10 mmHg	−0.27	−0.45 to −0.08	0.004	−0.19	−0.37 to −0.01	0.034
Diastolic BP, day, per 10 mmHg	−0.27	−0.44 to −0.09	0.002	−0.18	−0.34 to −0.02	0.032
Diastolic BP, night, per 10 mmHg	−0.20	−0.40 to 0.01	0.056	−0.17	−0.36 to 0.02	0.082
Kidney Parameters
Estimated GFR, mL/min/1.73 m2	−0.46	−1.26 to 0.34	0.262	—	—	—
Creatinine	−0.15	−0.71 to 0.42	0.604	—	—	—
Urine MCR, mg/g	0.12	−0.04 to 0.29	0.138	—	—	—

CI = confidence interval; BP = blood pressure; GFR = glomerular filtration rate; MCR = microalbumin-to-creatinine ratio.

Multivariate model - adjusted for age, gender, diabetes, calcium channel blockers and diastolic BP.