Table 4.
Associations of systemic factors with number of flow voids (dependent variable) in hypertensive participants (n = 164 eyes).
| Univariate | Multivariate-adjusted | |||||
|---|---|---|---|---|---|---|
| β | 95% CI | P value | β | 95% CI | P value | |
| Age, per 10 years | −22.82 | −34.51 to −11.13 | <0.001 | −21.21 | −31.79 to −10.63 | <0.001 |
| Gender | −8.25 | −31.67 to 15.17 | 0.490 | −15.08 | −0.22 to 0.36 | 0.164 |
| Diabetes | −20.42 | 57.86 to 17.03 | 0.285 | −3.00 | −35.32 to 29.33 | 0.856 |
| Type of antihypertensive medications | ||||||
| Beta blockers | 9.30 | −17.66 to 36.26 | 0.499 | — | — | — |
| Calcium channel blockers | −19.12 | −41.53 to 3.30 | 0.095 | −24.48 | −44.43 to −4.53 | 0.016 |
| Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers | 4.02 | −18.86 to 26.90 | 0.731 | — | — | — |
| Others (diuretics, alpha 2 adrenergic agonist) | 7.99 | −21.24 to 37.23 | 0.592 | — | — | — |
| Numbers of antihypertensive medications | ||||||
| One | Reference | Reference | ||||
| Two | −6.67 | −32.27 to 18.92 | 0.609 | — | — | — |
| Three or more | 3.14 | −40.48 to 46.76 | 0.653 | — | — | — |
| BP control status | ||||||
| Intensive BP control | Reference | Reference | ||||
| Standard BP control | −5.34 | −32.54 to 21.87 | 0.701 | — | — | — |
| Poor BP control | −24.48 | −55.62 to 6.66 | 0.123 | — | — | — |
| Systolic BP | ||||||
| Systolic BP, overall, per 10 mmHg | −1.46 | −10.85 to 7.94 | 0.761 | — | — | — |
| Systolic BP, day, per 10 mmHg | −1.79 | −10.69 to 7.10 | 0.693 | — | — | — |
| Systolic BP, night, per 10 mmHg | −0.05 | −8.56 to 8.47 | 0.992 | — | — | — |
| Diastolic BP | ||||||
| Diastolic BP, overall, per 10 mmHg | 16.40 | 3.71 to 29.10 | 0.011 | 12.16 | −0.03 to 24.36 | 0.051 |
| Diastolic BP, day, per 10 mmHg | 15.19 | 28.62 to 27.53 | 0.016 | 10.13 | −1.35 to 21.61 | 0.084 |
| Diastolic BP, night, per 10 mmHg | 15.15 | 1.27 to 29.03 | 0.032 | 13.89 | 0.61 to 27.17 | 0.040 |
| Kidney Parameters | ||||||
| Estimated GFR, mL/min/1.73 m2 | 49.16 | −7.53 to 105.86 | 0.089 | — | — | — |
| Creatinine | −4.39 | −45.13 to 36.35 | 0.833 | — | — | — |
| Urine MCR, mg/g | −8.56 | −23.87 to 6.76 | 0.274 | — | — | — |
CI = confidence interval; BP = blood pressure; GFR = glomerular filtration rate; MCR = microalbumin-to-creatinine ratio.
Multivariate model - adjusted for age, gender, diabetes, calcium channel blockers and diastolic BP.