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. 2019 Apr 9;9:5815. doi: 10.1038/s41598-019-41759-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Third iteration of screening identifies Δhmx1. Screening of a transposon-disruption library in a Δqdr2 Δyor1 background led to identification of Δhmx1, a disruption of heme oxygenase, that increased both betaxanthin and dopamine titers in their respective production strains. (A) The Δhmx1 strain shows higher total fluorescence than WT in liquid culture. (B) The Δhmx1 strain produces 28.4 +/− 10.5% (s.e.m) more dopamine than WT after a 14 h growth period. Boxes represent the interquartile range (IQR; 25–75%). Whiskers represent the range of the data with the exception of outliers. Data points outside of the IQR +/− 1.5xIQR are considered outliers. Significance was determined using t-tests.