Table 4.
The effect of HPV genotyping testing in triaging women with ASCUS.
| Triage criteria using HR-HPV types | Sensitivity | Specificity | PPV | NPV | Referral rate (%) | ||||
|---|---|---|---|---|---|---|---|---|---|
| %(n/N) | 95%CI | %(n/N) | 95%CI | %(n/N) | 95%CI | %(n/N) | 95%CI | ||
| CIN2+ | |||||||||
| HPV16/18 | 65.5 (19/29) | 47.3, 80.1 | 91.2 (332/364) | 87.9, 93.7 | 37.3 (19/51) | 25.3, 51.0 | 97.1 (332/342) | 94.7, 98.4 | 13.0 |
| HPV16/18/52 | 79.3 (23/29) | 61.6, 90.2 | 82.4 (300/364) | 78.2, 86.0 | 26.4 (23/87) | 18.3, 36.6 | 98.0 (300/306) | 95.8, 99.1 | 14.8 |
| HPV16/18/52/58 | 89.7 (26/29) | 73.6, 96.4 | 77.2 (281/364) | 72.6, 81.2 | 23.9 (26/109) | 16.8, 32.7 | 99.0 (282/285) | 97.0, 99.6 | 21.9 |
| HPV16/18/33/52/58 | 93.1 (27/29) | 78.04, 98.09 | 75.8 (276/364) | 71.2, 79.9 | 23.5 (27/115) | 16.7, 32.0 | 99.3 (277/279) | 97.4, 99.8 | 29.3 |
| HR-HPV | 96.6 (28/29) | 82.8, 99.4 | 68.7 (250/364) | 63.7, 73.2 | 19.7 (28/142) | 14.0, 27.0 | 99.6 (250/364) | 97.8, 99.9 | 36.1 |
CIN2+, cervical intraepithelial neoplasia grade 2 or worse; 95% CI, 95% confidence interval; PPV, positive predictive value; NPV, negative predictive value; ASCUS, atypical squamous cells of undetermined significance.