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[18F]Fallypride binding in the rat prefrontal cortex and striatal regions (A), 5 mg/kg Clozapine N-oxide (CNO) induced a noticeable decline in receptor availability in the same rat (A). CNO induced occupancy on a group level at the dopamine D2/3 receptors in the prefrontal cortex (B,C) as well as dorsal (D,E) and ventral (F,G) striatum. Horizontal lines and ∗represents a significant effect of treatments, as measured with a one-way ANOVA (∗p < 0.05, ∗∗p < 0.01 and ∗∗∗p < 0.001).
