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. 2019 Apr 3;7:44. doi: 10.3389/fcell.2019.00044

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Copyright © 2019 Sanchez, Li, Dulong, Aimond, Lamartine, Liu and Sigaudo-Roussel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of CM100 on 3D human full-thickness reconstructed skin. RT-qPCR expression analysis of (A) stress markers p16 and p53 and (B) ECM gene MMP1, MMP2, COL1A1, and ELN expression after 5-day stimulation of 3D skin models with CM100 stimulation versus control CMØ. Gene expression was normalized with GAPDH. Results were compared and analyzed to control condition using ANOVA Dunnett’s test, ^∗P < 0.05.