Table 3.

Diagnostic statistic parameter values for each putative biomarker protein.

Putative biomarker	B-MYB	CIP-2a	TKTL1
ROC curve AUC ± SEM	0.788 ± 0.0724	0.885 ± 0.0578	0.937 ± 0.0383
AUC 95% CI	0.647–0.930	0.771–0.998	0.862–1.012
AUC DeLong Z statistics	3.99	6.66	11.4
AUC P vs. chance*	<0.0001	<0.0001	<0.0001
Youden's J index	0.472	0.678	0.833
Optimal decision threshold (ODT)**	800	2,380	1,720
% Accuracy at ODT	68.5	85.7	87.9
Sensitivity at ODT	0.913	0.909	0.933
Specificity at ODT	0.538	0.769	0.833
FP proportion at ODT	0.462	0.231	0.167
FN proportion at ODT	0.067	0.091	0.067
Likelihood ratio (+) at ODT	2.02	3.94	5.60
Likelihood ratio (-) at ODT	0.12	0.12	0.08
Predictive value (+) at ODT	0.48	0.64	0.78
Predictive value (-) at ODT	0.95	0.95	0.97
Odds Ratio value at ODT	16.333	33.333	70.000
Cost at ODT	0.189	0.140	0.103

^*Chance area = 0.5.

^**ODT, values of specific protein band densitometric integrated intensity (xE4).