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. 2019 Apr 3;10:691. doi: 10.3389/fimmu.2019.00691

Figure 4.

Figure 4

Immune pattern of monocytic myeloid derived suppressor cells (M-MDSCs) and polimorphonuclear (PMN)-MDSCs in EOC with different clinicopathological characteristics of patients. Examination of arginase 1 (ARG1) (A–C), indolamine 2,3-dioxygenase (IDO) (D–F), interleukin 10 (IL-10) (G–I), and transforming growth factor β (TGF-β) (J–L)-expressing M-/PMN-MDSCs in EOC patients with different clinicopathological characteristics. Samples from the peripheral blood (PB) (n = 47), peritoneal fluid (PF) (n = 29), and tumor tissue (TT) (n = 32) of patients with different Federation of Gynecology and Obstetrics (FIGO) stage (early vs. advanced) (A,D,G,J), histopathologic grading (low vs. high) (B,E,H,K) and Kurman and Shih type (I vs. II) (C,F,I,L) were examined by flow cytometry. The frequencies of ARG+/IDO+/IL-10+/TGF-β+M-/PMN-MDSC subsets (A–L) are shown as the percentage of the total respective subsets. The percentages of MDSC subsets from the PB/PF/TT were assessed in the same patients as described in Figure 1. Each point corresponds to an individual patient. Boxes indicate the 25 to 75th percentiles. The horizontal lines within the boxes are the median values and the whiskers indicate the minimum and maximum values. Asterisks show statistical significance (*p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001).