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. 2019 Apr 3;10:691. doi: 10.3389/fimmu.2019.00691

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Copyright © 2019 Okła, Czerwonka, Wawruszak, Bobiński, Bilska, Tarkowski, Bednarek, Wertel and Kotarski.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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High levels of blood circulating and tumor-infiltrating monocytic myeloid derived suppressor cells (M-MDSCs) are associated with poor survival. The percentages of MDSC subsets in the peripheral blood (PB) and tumor tissue (TT) were determined in the same patients as described in Figure 1. The overall survival (OS) values of the patients with high/low M-MDSCs in the PB (A) and high/low M-MDSCs in the TT (B) among mononuclear cells (MCs) are shown as Kaplan-Meier curves. Univariate analysis of OS in patients with EOC was performed using Kaplan Meier method based on MDSCs percentage; solid black line: values below median, intermittent red line: values above median. Statistical analysis of survival was performed by the log-rank (Mantel-Cox) analysis. Results were considered significant at p < 0.05.