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. 2019 Apr 3;10:687. doi: 10.3389/fimmu.2019.00687

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Copyright © 2019 Costa-García, Ataya, Moraru, Vilches, López-Botet and Muntasell.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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HLA-DR expression in NKG2C+ adaptive NK cells is uncoupled from phenotypic features associated to their differentiation profile. The expression of FcεRIγ, NKp30 and NKp46 NCRs, CD161, CD57, and ILT2 (LILRB1) was analyzed in NKG2C+ HLA-DR+ and NKG2C+ HLA-DR– circulating NK cells from seropositive individuals with NKG2C+ adaptive NK cell expansions. (A) Percentage of CD57, ILT2, NKp30, NKp46, CD161 positive, and FcεRIγ negative cells in CD56^dim NKG2C+ NK cells according to HLA-DR co-expression (mean ± SEM, n = 5). (B) Expression of HLA-DR and FcεRIγ in NKG2C+ and NKG2C– adaptive NK cells from two representative donors out of five studied. Inset numbers in lower panels indicate the proportions of HLA-DR in FcεRIγ + and FcεRIγ-NK cells.