Figure 2.

GC cellular populations over time for the set of stabilized literature parameters. The parameters calculated from evidence in the literature, adjusted to lead to stable populations. Affinity does not increase over time, MBC output is still significant at day 30 and PC output only reaches steady state at late time points, contrarily to experimental evidence (17). The ratio of T cells interacting with B cells never exceeds 35%, which results in insufficient competition for T cell help. In the figures above, germinal center cell counts are the average number of concurrent cells, while cells leaving the germinal center are accumulated per periods of 18 h. The shaded area depicts standard error (SE).