Table 1.
Parameter values and ranges of stability.
| Parameter | Lower bound | Fitted | Literature | Upper bound |
|---|---|---|---|---|
| rdivision | 0.10 | 0.11 | 0.11 (3, 22–26) | 0.13 |
| pmutation | 0 | 0.4 | 0.39 (26, 27) | 1 |
| rmigration | 0.11 | 0.13 | 0.17 (28) | 0.16 |
| rapoptosis | 0 | 0.21 | 0.10 (26) | 0.74 |
| rFDC encounter | 0.004 | 0.035 | 0.021 (26, 29) | ∞ |
| rT cell encounter | 0.26 | 1.92 | 0.07 (26, 27) | ∞ |
| ractivation | 0.19 | 1.20 | 2.00 (27) | 26 |
| rrecirculation | 0.54 | 1.08 | 0.49 (28) | ∞ |
| rexit | 0 | 2.2 | 1.36s (26, 27) | 4.0 |
| antigen_threshold | 0 | 0.22 | – | ∞ |
The table reports a parameter set found by fitting the model to the GC output experimentally measured by Weisel et al. (17) (Fitted), and a second set estimated from parameters found in the literature (Literature). The Lower and Upper bounds columns report the lower and upper ranges of stability. Units: h−1, except pmutation and antigen_threshold, which are unitless.