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(A to C) Helical wheel diagrams (A and B) and activity of α4 and α4M1 against P. aeruginosa (C). In contrast to our previously published data on activity against S. aureus, the first-generation SPLUNC1-derived AMPs are ineffective against P. aeruginosa, as shown by the kinetics of growth inhibition, which is negligible compared to the untreated control. This is the rationale for further optimization. Red circles denote amino acid substitutions. OD570, optical density at 570 nm.
