Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Mar 11;9(4):e01254. doi: 10.1002/brb3.1254

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 The Authors. Brain and Behavior published by Wiley Periodicals, Inc.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Glibenclamide attenuates brain edema and improves neurological outcomes in mice after intracerebral hemorrhage (ICH) by maintaining the integrity of the blood–brain barrier (BBB). (a) Compared to vehicle, glibenclamide significantly reduced the brain water content in the affected hemisphere after ICH. (b) Glibenclamide decreased the extravasation of Evans Blue in the brain after ICH. (c) Glibenclamide preserved the ICH‐induced degradation of the tight junction protein zona occludens‐1 (ZO‐1). (d) Glibenclamide improved neurological outcomes 3 and 7 days following ICH. (n = 4 in sham group, n = 6 in ICH group, *p < 0.05, **p < 0.01)