Figure 3.

Enhancement of UPR^mt With NR Is Cardioprotective in Mice Subjected to Chronic Pressure Overload

Mice were pre-treated with NR or vehicle for 3 days and subsequently subjected to TAC or sham-constriction. (A) Heart weight/body weight (HW:BW) ratio as a measure of cardiac hypertrophy. (B) Effect of NR on left ventricular ejection fraction (EF). (C) Representative M-mode echocardiography images. (D) Quantification of TUNEL⁺ cardiomyocytes in myocardial sections. (E) Changes in KDEL sequence-containing proteins assessed by immunoblotting. Data are mean ± SEM, n = 4 to 14/group; *p < 0.05. TAC = transverse aortic constriction; other abbreviations as in Figures 1 and 2.