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. 2019 Apr 3;13:303. doi: 10.3389/fnins.2019.00303

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Copyright © 2019 Gyengesi, Rangel, Ullah, Liang, Niedermayer, Asgarov, Venigalla, Gunawardena, Karl and Münch.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Decreased cerebellar volume at 6, 14 and 24 months. (A) The cerebellar volume of the GFAP-IL6 was found to be significantly decreased from 6 months compared to their WT littermates (B) Nissl stained representative sections at each time point demonstrating decreased cerebellar volumes from 6 months on in the GFAP-IL6 animals. Inserts showing the cellular disintegration of the cerebellar cell layers starting from 6 months of age. Data presented as mean ± SEM. ^∗ indicates p < 0.05, ^∗∗ indicates p < 0.01, ^∗∗∗ indicates p < 0.001, and ^∗∗∗∗ indicates p < 0.0001; two-way ANOVA, with Tukey post hoc test.