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. 2019 Apr 3;13:303. doi: 10.3389/fnins.2019.00303

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Copyright © 2019 Gyengesi, Rangel, Ullah, Liang, Niedermayer, Asgarov, Venigalla, Gunawardena, Karl and Münch.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Increased IL6 overexpression decreased PSD95 levels in the cerebellum in the GFAP-IL6 during aging but did not significantly affected synaptophysin levels. Protein levels of PSD95 (A) and synaptophysin (B) were measured at 3, 6, 14, and 24 months of age in both WT and GFAP-IL6 animals (n = 5 for each groups) using Western Blot analysis. Panels (A1,B1) show an example blot from each group; for the summary data, each band was normalized to the respective α-actin band, and the normalized values are plotted relative to control levels. ^∗p < 0.05, ^∗∗p < 0.005; two-way ANOVA with Tukey post hoc correction.