Table 4.
Summary of published case reports of DOACs used for LVT resolution.
| Author | Year | Country | Age | Gender | Co morbidities | Other medications | TSOAC used | Duration of anticoagulant | LVT resolution | Anticoagulation continuation | Complications |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Kaku3 | 2013 | Japan | 59 | Male | Mid-ventricular obstructive hypertrophic cardiomyopathy | None | Dabigatran 150 mg BID | 21 days | Thrombus resolved | Dabigatran resumed | None |
| Nakasuka et al.3 | 2014 | Japan | 42 | Male | Heart failure (NYHA class III), atrial fibrillation, tachycardia and pitting edema on the lower extremities, IBS | Heparin and warfarin for 1 day | Rivaroxaban 15 mg once daily | 7 days | Thrombus resolved | Unknown | None |
| Cross and Stewart4 | 2014 | New Zealand | 65 | Female | STEMI, history of SAH | None | Dabigatran 150 mg BID | 30 days | Thrombus resolved | Dabigatran stopped | None |
| Chung et al.5 | 2015 | Korea | 57 | Male | Acute stent insertion in the proximal left anterior descending artery & atrial fibrillation | Alteplase (0.9 mg/kg) IV | Dabigatran 110 BID | 7 days | Thrombus resolved | Patient switched to dabigatran 150 mg BID | None |
| Yanikoglu et al.6 | 2015 | Turkey | 55 | Male | Anterior MI since 6 years. EF= 45% | Previous warfarin (suffered from GI bleed due to noncompliance, INR = 7) | Apixaban 5 mg BID | 30 days | Thrombus resolved | Unknown | None |
| Kolekar et al.7 | 2015 | India | 61 | Male | Congestive heart failure, stroke, scar epilepsy, atrial fibrillation, diabetes, hypertension, and ventricular tachycardia | None | Dabigatran 110 mg BID for 4 months | 4 months | Thrombus resolved | Unknown | None |
| Ohashi et al.8 | 2015 | Japan | 78 | Male | Hypertension, paroxysmal atrial fibrillation and stenosis post PCI in the proximal left anterior descending artery 7 years ago | None | Dabigatran 110 mg BID | 18 days | Thrombus resolved | Dabigatran 110 mg BID for 6 months | None |
| Assadullah Azizi et al.9 | 2016 | Switzerland | 54 | Male | STEMI | DAPT | Rivaroxaban 20 mg everyday | 30 days | Thrombus resolved | Rivaroxaban was further continued for 3 months | Persistence of apical dyskinesia |
BID: twice daily; DAPT: dual antiplatelet therapy; EF: ejection fraction; GI: gastrointestinal; IBS: irritable bowel syndrome; LVT: left ventricular thrombus; MI: myocardial infarction; NYHA: New York Heart Association; PCI: percutaneous coronary intervention; SAH: subarachnoid hemorrhage; STEMI: ST-elevation myocardial infarction; TSOACs: target-specific oral anticoagulants.