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(a) Schematic diagram of the developed ring-hole PIA biochip with captured EGFR+ exosomes. (b) Real-time response of 18-pair sensing units upon exosome adsorption on the sensor surface. (c-d) SEM images of the sensor surface (c) before and (d) after exosome binding. Scale bar: 2 μm. Red squares indicate obvious exosome binding within the ring area after exosome binding.
