Time course of serum thyroglobulin, TSH, and maximum diameter of the soft tissue metastatic lesion in a patient with PPFP thyroid carcinoma. Radiation therapy (RT) and pioglitazone (Pio) administrations are indicated. To simplify the y-axis, TSH values are given ×100; for example, y-axis 16 = TSH of 0.16. The table below the graph shows, for each time point, all three metastasis dimensions in centimeters (craniocaudal × transverse × anteroposterior) and the metastasis volume, calculated by using the formula of a prolate ellipse.