Table 5.

Utility of Various Analytes for Monitoring CAH Treatment

Patients	Analyte	Physiology	Goals and Comments
All ages	Plasma renin	Volume status	Low to normal unless hypertensive
	Potassium	MC replacement	Goal is normal
	Sodium	GC and MC replacement	Goal is normal
	Testosterone	Total androgens	Goal is at or near normal
	Androstenedione	Mostly adrenal origin	Goal is at or near normal
	Sex hormone–binding globulin	Testosterone-binding protein	For calculation of free and bioavailable testosterone
	17OHP	Variable	Normal values indicate overtreatment
Men	Testosterone	Adrenal or gonadal origin	Interpret abnormal values in context of gonadotropins and androstenedione levels
	Gonadotropins	Gonadal axis status	Low indicates poor control
	Androstenedione	Mainly adrenal	Goal is <0.5× testosterone
	Semen analysis	Fertility	Goal is normal
Women	Follicular-phase progesterone	Mainly adrenal origin when elevated	Goal is <0.6 ng/mL (<2 nmol/L) for women trying to conceive