Table 3.
Analysis of Predictive Statistics and Receiver Operator Curve for Ultrasound Features for Thyroid Carcinoma in Children
| Variable | Sensitivity (95% CI) | Specificity (95% CI) | PPV (95% CI) | NPV (95% CI) | ROC (95% CI) |
|---|---|---|---|---|---|
| Nodule size >1 cm | 81% (71–89.1) | 32.1% (24.8–40) | 38% (30.7–45.7) | 76.9% (64.8–86.5) | 0.57 (0.51–0.62) |
| ≤25% solid nodule composition | 85% (75.3–92) | 46.2% (38.2–54.3) | 44.7% (36.7–53) | 85.7% (76.4–92.4) | 0.66 (0.6–0.71) |
| Nonisoechoic echogenicity | 83.5% (73.5–90.9) | 52.6% (44.4–60.8) | 47.8% (39.3–56.5) | 86% (77.3–92.3) | 0.68 (0.62–0.74) |
| Taller-than-wide | 21.2% (12.9–31.8) | 89.7% (83.9–94.0) | 51.5% (33.5–69.2) | 69% (62.1–75.3) | 0.56 (0.5–0.61) |
| Increased Doppler flow | 90.9% (82.2–96.3) | 25.9% (19–33.7) | 39.1% (31.9–46.7) | 84.4% (70.5–93.5) | 0.58 (0.54–0.63) |
| Presence of calcifications | 60% (48.4–70.8) | 85.8% (79.3–90.9) | 68.6% (56.4–79.1) | 80.6% (73.7–86.3) | 0.73 (0.67–0.79) |
| Infiltrative/microlobular margin | 51.9% (40.4–63.3) | 89.1% (83.1–93.5) | 70.7% (57.3–81.9) | 78.5% (71.7–84.3) | 0.71 (0.64–0.77) |
| Extrathyroidal extension | 16.2% (8.9–26.2) | 98.1% (94.5–99.6) | 81.2% (54.4–96.0) | 69.5% (63.0–75.6) | 0.57 (0.53–0.61) |
| All features combined | 58.7% (46.7–69.9) | 91.6% (85.8–95.6) | 78.6% (65.6–88.4) | 80.9% (74–86.6) | 0.8449 |
Abbreviations: NPV, negative predictive value; PPV, positive predictive value; ROC, receiver operator curve.