Table 3.

Proportion of Variance (R²_adj) Explained by Demographics and/or Metabolites for Measures of Glucose Homeostasis

	R 2 adj
SI (n = 922)
Age, sex, center	0.064
Age, sex, center, BMI	0.35
Age, sex, center, BMI, metabolites (n = 99, P < 6.82 × 10−5)	0.63
HOMAIR (n = 940)
Age, sex, center	0.0064
Age, sex, center, BMI	0.29
Age, sex, center, BMI, metabolites (n = 103, P < 6.82 × 10−5)	0.63
AIRg (n = 922)
Age, sex, center	0.073
Age, sex, center, BMI	0.11
Age, sex, center, BMI, metabolites (n = 6, P < 6.82 × 10−5)	0.21
HOMAB (n = 940)
Age, sex, center	0.024
Age, sex, center, BMI	0.19
Age, sex, center, BMI, metabolites (n = 45, P < 6.82 × 10−5)	0.45
SG (n = 922)
Age, sex, center	0.047
Age, sex, center, BMI	0.14
Age, sex, center, BMI, metabolites (n = 47, P < 6.82 × 10−5)	0.27
DI (n = 922)
Age, sex, center	0.12
Age, sex, center, BMI	0.21
Age, sex, center, BMI, metabolites (n = 56, P < 6.82 × 10−5)	0.36
Fasting insulin (n = 979)
Age, sex, center	0.0033
Age, sex, center, BMI	0.23
Age, sex, center, BMI, metabolites (n = 79, P < 6.82 × 10−5)	0.56
Fasting glucose (n = 981)
Age, sex, center	0.12
Age, sex, center, BMI	0.22
Age, sex, center, BMI, metabolites (n = 26, P < 6.82 × 10−5)	0.64