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. 2019 Apr 8;12:1178646919840321. doi: 10.1177/1178646919840321

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© The Author(s) 2019

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 1. — Schematic overview of the Kynurenine pathway, showing the main enzymes and their products. Enzymes are listed in italic font in the figure. ACMSD indicates 2-amino 3-carboxymuconate-6-semialdehyde decarboxylase; 3-HAO, 3-hydroxyanthranilate 3,4-dioxygenase; IDO, indoleamine 2,3-dioxygenase; IDO2, indoleamine 2,3-dioxygenase 2; KATs, kynurenine aminotransferases; KMO, kynurenine 3-monooxygenase; NAD⁺, nicotinamide adenine dinucleotide; QPRT, quinolinate-phosphoribosyltransferase; TDO, tryptophan 2,3-dioxygenase.