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An approach to IDH-wildtype diffuse astrocytoma and anaplastic astrocytoma. See text for details. Abbreviations: IDH – isocitrate dehydrogenase; IHC – immunohistochemistry; ATRX – ataxia telangiectasia and mental retardation syndrome, X-linked; K27M – histone H3 K27M; G34R/V – histone H3.3 G34R or G34V; PA – pilocytic astrocytoma; GG – ganglioglioma; GBM – glioblastoma; NOS – not otherwise specified; NEC – not elsewhere classified
