Table 4.

sCR1 treatment for ischemic stroke.

Animals	Stroke models	Time of administration	Routes of injection	Time point of observations	Outcomes	Mechanisms	Refs
Sprague-Dawley rats	1 h MCAO	1 h before surgery	Intravenous injection of sCR1	1 h, 24 h after surgery	Reduced brain infarct volume and neurological motor deficits	Reduced neutrophil accumulation and inflammation; Reduced C4b deposition in the cortex	[387]
Sprague-Dawley rats	2 h MCAO	1 h before surgery	Intravenous injection of sCR1	2 h, 24 h after surgery	Reduced brain infarct size and neurological deficit scores	Inhibited neutrophil infiltration and C3b deposition in the brain	[388]
Adult male baboons	1.25 h MCAO	45 min before surgery	Intravenous injection of sCR1-sLex	2 h, 6 h, 12 h, 72 h and 10 days of post-ischemia	Increased brain infarct volume; Did not improve neurological functions	Not studied	[390]
Adult male baboons	1.25 h MCAO	45 min before surgery	Intravenous injection of sCR1	72 h and 10 days of post-surgery	Did not affect brain infarct volume and neurological scores	Not studied	[389]
7-day-old rats	Unilateral carotid artery ligation followed by transient hypoxia	24 h before surgery	Intraperitoneal injection of sCR1 or sCR1-sLex	24 h after surgery	Did not reduce infarct volume	Not studied	[300]
Mice	0.75 h MCAO	Immediately before MCAO	Administration of sCR1 or sCR1-sLex	24 h after stroke	Reduced brain infarct volume and neurological deficit score	Inhibited neutrophil and platelet accumulation in the brain	[24]