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. 2019 Apr 1;10(2):278–292. doi: 10.14336/AD.2018.0917

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Copyright: © 2019 Calvo et al.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 4. — Linear mixed model analysis in the serial blood study cohort. (A) Linear mixed model analysis showed a significant relationship among a faster disease progression and high COL19A1 levels from symptom onset, each dashed line corresponds to the COL19A1 levels from each patient. (B) Mean change from baseline in the ALSFRS-r score in patients that were monitored at 6-monthly intervals during a follow-up period of 24 months from the symptom onset that show COL19A1 levels above (green dot and line) and below (blue dot and line) average at first evaluation. Student's-t test was performed to analyze statistical differences between groups (P < 0.001). A total of 40 SALS patients from the serial blood study cohort were included.