Table 1.

General and clinical characteristics of the study subjects in the muscle biopsy study cohort.

Type of cohort (N)		Muscle biopsy cohort* (N = 87)
		ALS patients	ONP patients	Healthy controls
Patients' characteristics		(n =49)	(n = 14)	(n = 24)
Gender (n)	Female	15	8	19
	Male	34	6	5
Age at illness onset (mean ± SD)		57.02 ± 12.42	43.79 ± 16.02
Age at biopsy (mean ± SD)		58.65 ± 12.52	42.34 ± 25.89	55.07 ± 26.07
Disease duration, months (mean ± SD)		19.54 ± 25.15
Clinical Phenotype (n)	ALS, spinal	42
	ALS, bulbar	6
	ALS + FTD	1
	OMD		5
	SMA		5
	CIDP		1
	KD		1
	NMD		1
	AD (Early)		1
ALSFRS-r at biopsy (mean ± SD)		40.24 ± 6.20
El Escorial criteria at onset (n)	Unavailable	33
	Defined	1
	Probable	6
	Possible	5
	Suspected	4
Genetic Diagnosis (n)	SALS	26
	FALS	6
	SALS + FTD	2
	MND-FTD	1
	PLS-SALS	1
	PMA-SALS	1
	Unavailable	12

^*All subjects were of caucasian ethic group.

ALS, amyotrophic lateral sclerosis; SALS, sporadic ALS; FALS, familial ALS; ALSFRS-r, the revised ALS Functional Rating Scale; ONP, other neuropathies; FTD, frontal temporal dementia; OPMD, oculopharyngeal muscular dystrophy; SMA, spinal muscular atrophy; CIDP, chronic inflammatory demyelinating polyneuropathy; KD, Kennedy Disease; MND, motor neuron disease (cervical myelopathy); AD, Alzheimer Disease (early); PLS, Primary Lateral Sclerosis; PMA, Primary Muscular Atrophy.