Table 3.
General and clinical characteristics of sporadic ALS patients in the serial blood study cohort.
| Type of cohort (N) | Serial blood cohort * (N = 40)
|
|||||
|---|---|---|---|---|---|---|
| ALS patients (n =40) | ||||||
| Patients' characteristics | Onset | 6 months | 12 months | 18 months | 24 months | |
| Gender (n) | Female | 15 | ||||
| Male | 25 | |||||
| Age at illness onset (mean ± SD) | 57.02 ± 12.42 | |||||
| Disease duration, months (mean ± SD) | 57.53 ± 23.48 | |||||
| Clinical Phenotype (n) | SALS, UMN and LMN spinal | 25 | ||||
| SALS, UMN spinal | 1 | |||||
| SALS, LMN spinal | 14 | |||||
| ALSFRS-r (mean ± SD) | 27.8 ± 5.47 | 23.8 ± 5.94 | 19.6 ± 6.27 | 18.5 ± 6.76 | 17.6 ± 6.76 | |
| El Escorial criteria at onset (n) | Defined | 25 | ||||
| Possible | 4 | |||||
| Probable | 11 | |||||
| Forced vital capacity (FVC) (%) | 10.4 ± 6.11 | 14.6 ± 6.99 | 15.0 ± 10.44 | 17.8 ± 11.12 | 20.6 ± 15.74 | |
| Body mass index (BMI) (Kg/m2) | 26.5 ± 3.81 | 26.3 ± 3.82 | 25.9 ± 4.11 | 26.0 ± 3.71 | 25.3 ± 3.55 | |
| Genetic Diagnosis (n) | SALS | 40 | ||||
*
All subjects were of caucasian ethic group. SALS, sporadic ALS; UMN, upper motor neuron; LMN, lower motor neuron; FVC, forced vital capacity; BMI, body mass index.