Table 1.
Proinflammatory SA secretome in senescent cells, aged tissues, and human tissues.
| SASP Factors | Senescent cells | Aged tissues | Human tissues |
|---|---|---|---|
| Cytokines, chemokines, and regulators | |||
| IL-1α | ↑↑↑ | - | |
| IL-1β | ↑↑ | ↑↑ | |
| IL-6 | ↑↑↑ | ↑↑↑ | |
| IL-7 | ↑↑↑ | ↑↑ | ↑ |
| IL-13 | ↑↑ | - | ↑ |
| IL1R1 | ↑ | ↑ | |
| IL11 | ↑ | ↑↑↑ | |
| IL15 | ↑ | - | |
| IL6R | ↑ | ↑↑ | |
| IL27Rα | ↑ | - | |
| IL2RA | ↑ | ↑↑↑ | ↑ |
| IL-8 | ↑↑↑ | - | |
| GRO-α (CXCL1) | ↑↑↑ | - | ↑ |
| GRO-β (CXCL2) | ↑↑↑ | - | ↑ |
| GRO-γ (CXCL3) | ↑↑↑ | - | ↑ |
| MCP-1 (CCL2) | ↑↑↑ | ↑↑↑ | |
| MCP-2 | ↑↑↑ | - | |
| MIP-1α (CCL3) | ↑↑↑ | - | ↑ |
| MIP-3α | ↑↑ | ↑↑↑ | |
| TNF-α | - | ↑ | ↑ |
| TNF-β | - | ↑↑ | ↑ |
| sTNFRI(TNFRSF1B) | ↑↑ | ↑ | |
| OPG(TNFRSF11B) | ↑* | ↑ | |
| Other proinflammatory factors | |||
| MMP1 | ↑↑↑ | - | |
| MMP3 | ↑↑↑ | ↑↑ | |
| MMP10 | ↑↑↑ | - | |
| MMP12 | ↑↑ | ↑↑↑ | |
| MMP13 | ↑↑ | - | |
| MMP14 | ↑↑ | - | ↑ |
| TIMP1 | ↑↑↑ | ↑ | |
| iNOS | - | ↑↑↑ | ↑ |
| IGFBP2 | ↑ | - | ↑ |
| IGFBP3 | ↑ | ↑* | ↑ |
| IGFBP6 | ↑ | ↑ | ↑ |
| HGF | ↑ | ↑ | ↑ |
| EGFR | ↑ | ↑ | ↑ |
| FAS | ↑ | ↑ | ↑ |
| Reference | 144-146 | 24, 125 | TCGA data base |