Table 2.
Comparison of major key features defining age-related chronic inflammation.
| Age-related inflammation/molecular inflammation | Inflammaging | Senoinflammation | |
|---|---|---|---|
| Oxidation | Sirt1, PPAR, FOXOs, SOD, CAT, PTK/PTP | Sirt1, Notch | FOXOs, SOD, CAT, LCK, SRC, PTK/PTP |
| Inflammation | COX-2, iNOS, TNFα, IL-1,6, AMs | TNFα, IL-6 | COX-2, iNOS, TNFα, IL-1,6 |
| Cytokine/Chemokines | IL-7, IL-2RA, CXCL1,2,3, MCP-1, CCL3 | TGFβ, IL-8, TNFα | cytokines, chemokines, MMPs, GFs, IGFBPs |
| Apoptosis | p53, p21, Bax | ||
| Autophagy | mTOR | mTOR | mTOR |
| Dysregulated metabolism | leptin, adiponectin, anabolism, catabolism | ||
| ER stress | IRE, PERK, ATF4,6 | ||
| Insulin resistance | IRS-Ser-p, Akt | ||
| Inflammasome | NLRP3 | ||
| Reference | 6-9, 12-15 | 10, 11, 54 | 6-9, 12-15, 23-25, 42, 125 |