Table 1.
Functional enrichment of genes on the whole genome of six histone modifications
| Term type | Term name | P-value | Term type | Term name | P-value |
|---|---|---|---|---|---|
| H3K4me1 | |||||
| BP | Cell adhesion | 1.42E-06 | CC | Cytoskeleton | 2.90E-03 |
| BP | Axon guidance | 2.86E-05 | CC | Growth cone | 2.15E-02 |
| BP | Nervous system development | 1.91E-04 | KEGG | Arrhythmogenic right ventricular | 5.82E-03 |
| BP | Signal transduction | 1.92E-04 | Cardiomyopathy (ARVC) | ||
| BP | Neuron development | 2.68E-02 | KEGG | Axon guidance | 2.79E-02 |
| BP | Cerebellar granule cell differentiation | 4.35E-02 | KEGG | Hippo signaling pathway | 4.32E-02 |
| H3K4me3 | |||||
| BP | Intracellular signal transduction | 7.16E-04 | BP | Adult behavior | 6.93E-03 |
| BP | Signal transduction | 1.22E-03 | MF | Extracellular-glutamate-gated ion channel | 2.77E-03 |
| BP | Nervous system development | 2.63E-03 | Activity | ||
| BP | Chemical synaptic transmission | 2.88E-02 | KEGG | Neuroactive ligand-receptor interaction | 6.24E-03 |
| H3K9me3 | |||||
| BP | Heterophilic cell-cell adhesion | 1.87E-07 | BP | Regulation of RNA splicing | 9.41E-03 |
| BP | Cell adhesion | 1.06E-04 | BP | Regulation of alternative mRNA splicing | 1.58E-02 |
| BP | Nervous system development | 6.27E-04 | BP | Chemical synaptic transmission | 3.35E-02 |
| BP | Regulation of neuron projection | 4.09E-03 | BP | Cerebellar granule cell differentiation | 3.98E-02 |
| Development | MF | Calcium ion binding | 1.25E-05 | ||
| BP | Signal transduction | 5.41E-03 | KEGG | Cell adhesion molecules (CAMs) | 2.10E-02 |
| H3K27ac | |||||
| BP | Signal transduction | 7.03E-05 | BP | Regulation of RNA splicing | 2.08E-02 |
| BP | Nervous system development | 7.47E-05 | BP | Cytoskeleton organization | 3.57E-02 |
| BP | Neuron cell-cell adhesion | 2.31E-04 | MF | Actin binding | 1.20E-04 |
| BP | Neuron development | 5.28E-03 | CC | Growth cone | 1.83E-04 |
| BP | Glutamate receptor signaling pathway | 5.76E-03 | MF | Protein kinase activity | 1.15E-02 |
| BP | Brain development | 1.57E-02 | KEGG | Neuroactive ligand-receptor interaction | 1.06E-02 |
| H3K27me3 | |||||
| BP | Social behavior | 9.15E-05 | BP | Cerebellar granule cell differentiation | 3.89E-02 |
| BP | Signal transduction | 5.10E-04 | MF | Calcium ion binding | 7.03E-05 |
| BP | Nervous system development | 2.97E-03 | MF | Cell adhesion molecule binding | 1.65E-04 |
| BP | Regulation of RNA splicing | 8.99E-03 | CC | Growth cone | 1.55E-02 |
| H3K36me3 | |||||
| BP | Heterophilic cell-cell adhesion | 4.04E-07 | CC | Neuron projection | 4.32E-03 |
| BP | Signal transduction | 2.27E-03 | MF | Actin binding | 7.37E-03 |
| BP | Cell adhesion | 1.25E-02 | KEGG | Neuroactive ligand-receptor interaction | 4.97E-02 |
| BP | Neuron differentiation | 3.37E-02 |