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Synthesis of common intermediate 10 from 4-(4-hydroxyphenyl)-2-butanonea
aReagents and conditions: (a) 5-bromovaleric acid methyl ester, K2CO3, 50 °C, DMF, 96%; (b) i: trimethylorthoformate, p-TsOH, MeOH; ii: Uridine, 2M HCl in dioxane, DMF; (c) LiOH, MeOH/H2O, 97%, 2 steps; (d) H-Ala-Wang resin, HBTU, DIPEA, DMF; (e) DIAD, PPh3, tetrachlorophthalimide, DMF/THF; (f) EDA, DMF.
