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Mefloquine causes a concentration-dependent decrease in intracellular GSH levels. The GSH content of control (a) and transfected (b) primary rat cortical neurons was determined after 24-hour incubations with graded concentrations of mefloquine using monochlorobimane, a fluorescent probe for GSH. Data represent mean ± SEM (bars) values from 3 independent experiments with n ≥ 24. *Significant difference between values from control and mefloquine-treated neuronal cells (p<0.05).
