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Heatmaps of PTPN14 (left) and PTP1B (right) specificity on pY library peptide array. PTPN14 exhibits a clear preference for glycine (G) in the Z (+1) position and tryptophan (W) in the X (−1) position. PTP1B exhibits different sequence selectivity, where proline (P) is disfavored at Z (+1) position.
