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. 2019 Apr 3;10:269. doi: 10.3389/fphar.2019.00269

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Copyright © 2019 Qin, Rosli, Deo, Cao, Walsh, Tate, Alexander, Donner, Horlock, Li, Kiriazis, Lee, Bourke, Yang, Murphy, Du, Gao and Ritchie.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ac_2-26 reduces systemic inflammation 48 h post I-R injury in vivo. Circulating levels of (A) total white blood cells (WBC), (B) neutrophils, (C) lymphocytes and (D) monocytes in blood collected from sham, vehicle- and Ac_2-26-(1 mg/kg/day, i.v.)-treated mice, 48 h post I-R. ^#P < 0.05, ^##P < 0.01 versus sham, ^∗P < 0.05 versus vehicle-treated mice. One-way ANOVA with Dunnett’s post hoc test. Data were presented as mean ± SEM, with number of mice per group. n = 6 (sham), n = 7 (I-R + vehicle), and n = 8 (I-R + Ac_2-26).