Figure 4.

Clonotypic diversity of MF. Contribution of the dominant clonotypes of TCRα, TCRβ, and TCRγ relative to the tumor DNA enrichment of the sample. Note that for samples MF4_2T, MF4_3P, MF5_1T, MF5_2P, MF7_1T, MF7_2P, MF8P, MF9P, MF11T, and MF11_1P, the proportion of the dominant TCRγ clonotype is approximately equal to the proportion of tumor DNA in the samples, indicating that all tumor cells share the same TCRγ clonotype. However, in the same samples, the relative frequency of the dominant TCRα and TCRβ clonotypes is only 15% (range, 6.52-30.89), indicating that other clonotypes are found in tumor-derived DNA.