Table 1.
Transplant type (or no 7/8 or 8/8 URD/CB transplant) by recipient ancestry divided into recent (January 2012-November 2017) vs earlier (October 2005-December 2011) periods
| Patient ancestry group | Transplant type, n (%) | Total patients, N (%) | |||
|---|---|---|---|---|---|
| 8/8 URD* | 7/8 URD | CB | No URD or CB | ||
| Early patients | 273 (48) | 127 (22) | 138 (24) | 32 (6) | 570 (100) |
| European (not Southern) | 203 (63) | 68 (21) | 48 (15) | 3 (1) | 322 (100) |
| Northwestern European | 77 | 21 | 10 | 1 | 109 |
| Eastern | 62 | 18 | 15 | 0 | 95 |
| Mixed European | 64 | 29 | 23 | 2 | 118 |
| Southern European | 20 (36) | 13 (24) | 17 (31) | 5 (9) | 55 (100) |
| Non-European (not African) | 41 (33) | 28 (22) | 51 (40) | 6 (5) | 126 (100) |
| Asian | 11 | 11 | 23 | 0 | 45 |
| White Hispanic | 14 | 12 | 16 | 4 | 46 |
| Middle Eastern | 6 | 1 | 4 | 0 | 11 |
| Mixed non-European | 10 | 4 | 8 | 2 | 24 |
| African | 9 (13) | 18 (27) | 22 (33) | 18 (27) | 67 (100) |
| Recent patients | 450 (61) | 92 (12) | 181 (25) | 19 (3) | 742 (100) |
| European (not Southern) | 319 (78) | 38 (9) | 54 (13) | 0 (0) | 411 (100) |
| Northwestern European | 121 | 13 | 13 | 0 | 147 |
| Eastern | 93 | 9 | 17 | 0 | 119 |
| Mixed European | 105 | 16 | 24 | 0 | 145 |
| Southern European | 34 (44) | 14 (18) | 28 (36) | 2 (3) | 78 (100) |
| Non-European (not African) | 80 (46) | 26 (15) | 63 (36) | 6 (3) | 175 (100) |
| Asian | 21 | 4 | 24 | 1 | 50 |
| White Hispanic | 20 | 11 | 16 | 4 | 51 |
| Middle Eastern | 9 | 3 | 7 | 0 | 19 |
| Mixed non-European | 30 | 8 | 16 | 1 | 55 |
| African | 17 (22) | 14 (18) | 36 (46) | 11 (14) | 78 (100) |
| All patients | 723 (55) | 219 (17) | 319 (24) | 51 (4) | 1312 (100) |
Africans included African Americans or African ancestry patients from the Caribbean or Africa. Non-European mixes had at least partial non-European origins excluding those who self-identified as black.
Statistical comparisons of receipt of 8/8 HLA-allele matched URD transplants in recent vs early periods: 61% in all recent period patients vs 48% in early patients (P < .001). In ancestry subgroups, the comparisons were European patients (not southern) 78% in recent patients vs 63% in early patients (P < .001), Southern European patients 44% vs 36% (P = .511), non-Europeans (not African) patients 46% vs 33% (P = .029), and African patients 22% vs 13% (P = .275).