Table 1.
Patient 1: CMML-1 | Patient 2: CMML-0 | Patient 3: CMML-1 | ||||
---|---|---|---|---|---|---|
Presurgical | Postsurgical | Presurgical | Postsurgical | Presurgical | Postsurgical | |
WBC, ×109/L | 5.48 | 346.9 | 20.3 | 119.8 | 9.9 | 104 |
Hemoglobin, g/dL | 11.1 | 8.4 | 13.8 | 12.3 | 7.7 | 9.2 |
Hematocrit, % | 36.3 | 25.6 | 41.4 | 37.1 | 24 | 28 |
Platelet count, ×109/L | 126 | 132 | 70 | 130 | 71 | 83 |
Absolute band count, ×109/L | 0 | 93.4 | 0 | 32.3 | 0 | 9 |
Absolute neutrophil count, ×109/L | 3.48 | 134 | 13.9 | 45.5 | 7.72 | 60.32 |
Absolute lymphocyte count, ×109/L | 1.25 | 6.92 | 3.7 | 3.6 | 1.29 | 3.12 |
Absolute monocyte count, ×109/L | 0.54 | 44.9 | 2.6 | 31.1 | 0.59 | 8.32 |
Absolute eosinophil count, ×109/L | <0.03 | 0 | 0.1 | 0 | 0.2 | 1.04 |
Absolute basophil count, ×109/L | 0.16 | 3.4 | 0.1 | 0 | 0 | 0 |
Absolute metamyelocyte count, ×109/L | 0 | 20.7 | 0 | 4.8 | N/A | N/A |
Absolute myelocyte count, ×109/L | 0 | 27.6 | 0 | 1.2 | N/A | N/A |
Absolute blast count, ×109/L | 0 | 6.92 | 0 | 0 | N/A | N/A |
LDH, U/L | 134 | 1289 | 245 | 951 | 155 | 341 |
Creatinine, mg/dL | 0.73 | 0.97 | 1.1 | 2 | 1.44 | 1.81 |
AST, U/L | 13 | 51 | 30 | 6987 | 17 | 20 |
ALT, U/L | 13 | 40 | 23 | 3316 | 16 | 19 |
Total bilirubin, mg/dL | 0.6 | 3.9 | 0.9 | 2.4 | 0.4 | 0.4 |
Alkaline phosphatase, U/L | 133 | 312 | 49 | 229 | 97 | 86 |
Lactate, mg/dL | N/A | 18 | N/A | 12.4 | N/A | N/A |
Somatic mutations | TET2 (2), SRSF2, ASXL1, SETBP1, CBL, FLT3-TKD | TET2, SRSF2, KRAS |
ALT, alanine aminotransferase; AST, aspartate aminotransferase; LDH, lactate dehydrogenase; N/A, not applicable; WBC, white blood cell.