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. Author manuscript; available in PMC: 2019 Dec 1.
Published in final edited form as: Int J Biochem Cell Biol. 2018 Oct 19;105:123–133. doi: 10.1016/j.biocel.2018.10.006

Figure 3.

Figure 3.

Crystal structure of an anti-EphA2 scFv Ab in complex with the ligand-binding domain of EphA2. The scFv variable light chain is pink, the variable heavy chain is red, and the EphA2 receptor is cyan. A long loop of the D2 heavy chain penetrates a hydrophobic surface cavity of the EphA2 in a way very similar to Ephrin binding to Eph.