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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: Curr Opin HIV AIDS. 2019 May;14(3):194–204. doi: 10.1097/COH.0000000000000541

Figure 1. HIV adaptation to HLA within-host.

Figure 1.

After infection is established by (usually) a single transmitted/founder virus (red), descendant within-host viral populations display progressively increasing adaptation to host HLA. Immune escape mutations can, at least in theory, accumulate until HIV has fully adapted to host HLA (shown here by the virus population that gradually shifts to the same color as the host).