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Gene-gene interaction of MMP-2 and TIMP-2 in acne patients and healthy controls. The combined effects of MMP-2 (-1306) C>T and TIMP-2 (-418) G>C polymorphisms were analyzed by gene interaction analysis. CT-GG and CT-GC genotype in patients with acne vulgaris were significantly higher than those in normal controls (p<0.001, OR=0.258; p <0.05, OR=0.332). MMP-2 and TIMP-2 gene polymorphism in acne.
