Fig. 3. (A) Total ADC pharmacokinetic study in SCID mice after a single intravenous ADC dose of 3 mg kg–1. Clearance was 15.8 and 37.6 mL per day per kg respectively for ADC-PSAR12 and ADC-PSAR0, as calculated by two-compartmental model analysis. (B) Antitumor activity in SCID/BT-474 breast cancer model following a single intravenous ADC dose of 3 mg kg–1. No body-weight changes were observed during the study. CR = complete remission.
